RNA-DNA differences are generated in human cells within seconds after RNA exits polymerase II.
Published: Cell Reports 2014 Mar 13; 6(5):906-15. @...
NIH Research: March 2014
March 1, 2014
Senataxin mutations elicit motor neuron degeneration phenotypes
and yield TDP-43 mislocalization in ALS4 mice and human patients
May 3, 2018
SETX ALS4 mice thus recapitulated ALS disease phenotypes in association with TDP-43 mislocalization and provided insight into the basis for TDP-43 histopathology, linking SETX dysfunction to common pathways of ALS motor neuron degeneration.