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A SUMO-dependent interaction between Senataxin and the exosome, disrupted in the neurodegenerative disease AOA2, targets the exosome to sites of transcription-induced DNA damage. Published: Advance October 8, 2013, doi:10.1101/gad.224923.113 Authors: Patricia Richard, Shuang Feng and James L. Manley Link to article: http://genesdev.cshlp.org/content/27/20/2227.long Senataxin (SETX) is an RNA/DNA helicase implicated in transcription termination and the DNA damage response and