top of page
Search

Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Pro

  • nicksanzo
  • Feb 1, 2018
  • 1 min read

Dr. Grunseich and colleagues found that patients’ cells with a senataxin mutation have fewer R-loops. They showed that having fewer R-loops decreases BAMBI expression and consequently increases TGFb signaling. Nascent RNAs form Rloops in gene promoters that facilitate transcription by disrupting DNA methylation in more than 1,200 human genes.

You can read the full paper here: https://doi.org/10.1016/j.molcel.2017.12.030

 
 
 

Recent Posts

See All
Beyond DNA: March 2016

Sequence variation in the RNA Dr. Cheung and her colleagues study RNA. Traditionally one thinks that DNA contains information for...

 
 
 
Featured Posts
Recent Posts
Search By Tags
Archive
Follow Us
  • Facebook Basic Square
  • Twitter Basic Square
  • Google+ Basic Square
bottom of page