Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Pro
- nicksanzo
- Feb 1, 2018
- 1 min read
Dr. Grunseich and colleagues found that patients’ cells with a senataxin mutation have fewer R-loops. They showed that having fewer R-loops decreases BAMBI expression and consequently increases TGFb signaling. Nascent RNAs form Rloops in gene promoters that facilitate transcription by disrupting DNA methylation in more than 1,200 human genes.
You can read the full paper here: https://doi.org/10.1016/j.molcel.2017.12.030
Recent Posts
See AllThe ALS4 team, Christopher Grunseich, MD, and Vivian G. Cheung, MD, with the National Institutes of Health recently published the...
SETX ALS4 mice thus recapitulated ALS disease phenotypes in association with TDP-43 mislocalization and provided insight into the basis...
Sequence variation in the RNA Dr. Cheung and her colleagues study RNA. Traditionally one thinks that DNA contains information for...