RNA-DNA differences are generated in human cells within seconds after RNA exits polymerase II.
Published: Cell Reports 2014 Mar 13; 6(5):906-15. @...
NIH Research: March 2014
March 1, 2014
Senataxin Mutation Reveals How R-Loops Promote
Transcription by Blocking DNA Methylation at Gene
February 1, 2018
Dr. Grunseich and colleagues found that patients’ cells with a senataxin mutation have fewer R-loops. They showed that having fewer R-loops decreases BAMBI expression and consequently increases TGFb signaling. Nascent RNAs form Rloops in gene promoters that facilitate transcription by disrupting DNA methylation in more than 1,200 human genes.