Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Pro

Dr. Grunseich and colleagues found that patients’ cells with a senataxin mutation have fewer R-loops. They showed that having fewer R-loops decreases BAMBI expression and consequently increases TGFb signaling. Nascent RNAs form Rloops in gene promoters that facilitate transcription by disrupting DNA methylation in more than 1,200 human genes.

You can read the full paper here: https://doi.org/10.1016/j.molcel.2017.12.030