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Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters

February 1, 2018

Dr. Grunseich and colleagues found that patients’ cells with a senataxin mutation have fewer R-loops. They showed that having fewer R-loops decreases BAMBI expression and consequently increases TGFb signaling. Nascent RNAs form Rloops in gene promoters that facilitate...

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Senataxin mutations elicit motor neuron degeneration phenotypes and yield TDP-43 mislocalization in ALS4 mice and human patients

May 3, 2018

Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters

February 1, 2018

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RNA-DNA differences are generated in human cells within seconds after RNA exits polymerase II.

Published: Cell Reports 2014 Mar 13; 6(5):906-15. @...

NIH Research: March 2014

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Senataxin Mutation Reveals How R-Loops Promote Transcription by Blocking DNA Methylation at Gene Promoters

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